Cells and Genomes, Cell Chemistry and Bioenergetics, DNA, Chromosomes, and Genomes, DNA Replication, Repair, and Recombination, How Cells Read the Genome: From DNA to Protein, Control of Gene Expression, Principles and Methodology of Recombinant DNA, Membrane Transport of Small Molecules and the Electrical Properties of Membranes, Intracellular Compartments and Protein Sorting, Intracellular Membrane Traffic, Cell Signaling, The Cytoskeleton, Cell Junctions and Extracellular Matrix. Note: Not to be taken for credit with LS 541

Introduction to life, cellular organization and cell division, Introduction to Physiology Anatomy: Description of human primary tissues, Neurons, nerves and nervous systems engineering application, Sensory system (vision, hearing, taste, external and internal sensing), Human bones and skeleton and application, Integumentary system, Muscles and human movement and engineering application, Circulation and Cardiovascular systems engineering application, Kidneys and excretion system and engineering application, Respiratory system and engineering application, Hormones and Endocrine Function, Digestive system, Immune response mechanisms, Reproduction. Note: Not to be taken for credit with LS 502

Engineering calculations and conservation laws, bioreactor design and operation, biomechanics, bioinstrumentation, biosensor and biosignals, bioimaging, biomaterials, drug delivery concept, tissue engineering, bioinformatics, regulatory, ethics, and entrepreneurship.

Basic concept and scope of statistics in our everyday and scientific inquiry, descriptive statistics, data, distribution, variance, and relation, probability, probability variable, probability distribution in life science, hypothesis testing for population mean and variance, hypothesis testing: PersonTime Data, ANOVA testing to compare several treatments, population mode and inferences, simultaneous confidence intervals, ANOVA testing for completely randomized block design and repeated measures design, regression and correlation methods (in biological and diseasesbased data), design and analysis techniques for epidemiologic studies, vital statistics for death, fertility, and morbidity ratio.

Introduction to Computational Modeling in Bioengineering, ODE Models in Biology: Enzyme Kinetics, population dynamics, gene circuits, PDE Models: Diffusion & Transport: Diffusion, heat transfer, tumor growth, wound healing, cardiovascular systems, aerosol drug delivery, and angiogenesis, Reaction–Diffusion & Pattern Formation: Turing patterns, morphogenesis, skin pattern, Stochastic Modeling of Gene Expression: Stochastic process, noise in gene circuits, Biological Networks: Network theory, signaling networks, Agent-Based Modeling (ABM) Basics: Foundations of ABM, agents, environments, population & epidemiology models, Multiscale Modeling: Linking ODE, PDE, and ABM: Multiscale cancer models, scaling up ABMs, Case Studies & Student Projects.

Introduction to Materials Science and Engineering, Properties and classification of Biomaterials, Classes of materials used in medicine, Biological chemistry, Biology and Medicine, Biomaterials in tissue interactions (immune response, degradation, sterilization), Biochemical Testing of Biomaterials (or toxicity and biocompatibility), Design & processing of biomaterials (additive manufacturing, coatings, failure modes), Applications of Bio-Materials in Medicine, Biology and artificial organs, Application of Biomaterials in Tissue Engineering, Implants, Devices, and Biomaterials (stents, heart valves, orthopedic implants, drug-eluting systems), New Products and Standards (ASTM/ISO standardization and risk factors).

Transport system in biological system; Transcellular and physiological transport system; Conservation relations for fluid transport, dimensional analysis, and scaling; Fluid flow in the circulation and tissue, Mass transport in biological systems; Mass transport and biochemical interaction, Energy transport in biological system.

Introduction to tissue engineering, Dynamics of extracellular extraction, Engineering the functional tissue, Bioreactor design, In-vivo synthesis of tissue engineering, Scaffold and biopolymer, Transplantation of cells and tissue, and Stem cells.

Principles of controlled release, water solubility of drugs, epithelial barriers, nanotechnologies, and routes for drug delivery and targeting, long-acting injections and implants, transdermal and nasal drug delivery, drug delivery to the central nervous system, gene delivery systems.

Fundamental conservation principles. Fluid dynamics in biological systems. Numerical techniques. Parameter estimation. Finite difference. Numerical integration. Finite element methods. Model physiological functions. Biological system behavior prediction.

Foundational understanding of Anatomy and Physiology. Mechanics of muscles, tendons, ligaments, menisci, and Bones. Application of motion equations. Human movement. Analytical and numerical methods of biomechanics. Experimental techniques in biomechanical research.

Applying scaling laws and continuum mechanics to biomechanics. Exploring multiple scales from molecules to cells and tissues. Tissue structure and its impact on macroscopic properties. Chemical and electrical effects on mechanical behavior. Cell mechanics and biomembranes. Studying structures at tissue, cellular, and molecular levels using theoretical and experimental techniques.

Studying how bone, cells, and collagen react to forces. Exploring insights into material structure impacting biomechanics. Development of high-performance biomimetic materials.

Overview of Biophotonics. Basic Principles of Light. Optical Fibers for Biophotonics Applications. Fundamentals of Light Sources. Fundamentals of Optical Detectors. Light-Tissue Interactions. Optical Probes and Biosensors. Microscopy. Spectroscopic Methodologies. Optical Imaging Procedures. Biophotonics Technology Applications.

Overview of Biomedical Instrumentation. Sensors and Transducers. Signal Filtering and Amplification. Data Acquisition and Signal Processing. Electrocardiography. Electroencephalography. Digital Hearing Aids. Mobile Health, Wearable Health Technology and Wireless Implanted Devices. Safety of Biomedical Instruments and Devices.

Introduction to Sensor-Based Measurement Systems. Transducer Technologies. Resistive, Reactance Variation, and Electromagnetic Sensors. Temperature and pressure sensors. Electrochemical and chemical biosensors. Optical sensors. Signal Conditioning. Self-Generating Sensors. Digital and Intelligent Sensors. Miniaturization and Microfabrication. Biosensor Characterization. Bioanalytical Applications. Emerging Trends in Biosensors. Regulatory and Ethical Considerations. Future Directions and Challenges.

Discrete- and continuous-time signals; basic system properties. Linear time-invariant systems; convolution. Frequency domain analysis; filtering; sampling. Laplace and Fourier transform; transfer functions; poles and zeros; transient and steady-state response. Z-transforms. Dynamic behavior and PID control of first- and second-order processes. Stability. Applications to biological systems, such as central nervous, cognitive, and motor systems.

Introduction. System Theory. Image Processing. Endoscopy. Microscopy. Magnetic Resonance Imaging. X-ray Imaging. Computed Tomography. X-ray Phase Contrast: Research on a Future Imaging Modality. Emission Tomography. Ultrasound. Optical Coherence Tomography.

Quality control, regulatory affairs, quality assurance, practices, documentation, process validation, ethical considerations, biotechnology operations, biomanufacturing, non-clinical development, clinical development, and project management.

Cell and cell growth, How Cell Works (Enzyme as protein, amino acid, central dogma, protein synthesis), Enzyme kinetics, Enzyme Immobilization, Bioreactor (classification and choices based on cultivation method), Bioreactor Design - Batch and Continuous Stirred-Tank Reactor (CSTR), Bioreactor consideration in Immobilized Cell system (Active and Passive immobilization, Diffusion), Scale-up of Bioreactors, Operation and Control (Scale-up and its difficulties, Bioreactor Instrumentation and Control, Sterilization process), Recovery and Purification of Product, Applications of Bioreactors (for animal cell culture, tissue engineering, vaccine development, hormone/enzyme engineering, waste water treatment). Note: Not to be taken for credit with CHE 524 or CHE 534

Microbial growth kinetics, bioenergetics, biological treatment processes, land treatment, suspended-growth and fixed-film processes, composting, hazardous waste management, and bioremediation.

Human genome, structure, function and variation; clinical cytogenetics, epigenetics and developmental genetics, genetic disorders and genomic medicine; genetic counseling, prenatal screening and diagnosis; ethical issues in genetics and genomics.

Advanced topics are selected from the broad area of bioengineering. The contents of the course will be provided in detail one semester in advance of that in which it is to be offered.

Graduate students are required to attend the seminars by faculty members, visiting scholars, and fellow graduate students. Additionally, each student must present at least one seminar on a timely research topic. Among other things, this course is designed to give the students an overview of research in BIOE, and a familiarity with research methodology, journals, and professional societies in his discipline. Graded on a Pass or Fail basis.

This course is intended to allow M.Sc. students to conduct research-related independent study. The faculty offering the course should submit a research plan to be approved by the BIOE Graduate Program Committee. At the end of the course, the student should submit a report and present his work to the Department Graduate Committee. Graded on a Pass or Fail basis.

The student has to undertake and complete a research topic under the supervision of a faculty member in order to probe in depth a specific problem in Bioengineering. Graded on a Pass or Fail basis.

The student will undertake and conduct an industrial research project related to bioengineering under the supervision of a faculty member. Subsequently, the students shall acquire skills and gain experience in developing and running an actual industry-based project. This project culminates in the writing of a technical report and an oral technical presentation in front of a board of professors and industry experts.

Advanced topics are selected from the broad area of bioengineering. The contents of the course will be provided in detail one semester in advance of that in which it is to be offered.

Advanced topics are selected from the broad area of bioengineering. The contents of the course will be provided in detail one semester in advance of that in which it is to be offered.

Advanced topics are selected from the broad area of bioengineering. The contents of the course will be provided in detail one semester in advance of that in which it is to be offered.

Graduate students are required to attend the seminars by faculty members, visiting scholars, and fellow graduate students. Additionally, each student must present at least one seminar on a timely research topic. Among other things, this course is designed to give the students an overview of research in BIOE, and a familiarity with research methodology, journals, and professional societies in his discipline. Graded on a Pass or Fail basis.

This course is intended to allow Ph.D. students to conduct research-related independent study. The faculty offering the course should submit a research plan to be approved by the BIOE Graduate Program Committee. At the end of the course, the student should submit a report and present his work to the Department Graduate Committee. Graded on a Pass or Fail basis. Pre-requisite: Instructor’s Consent

This course is intended to allow Ph.D. students to conduct research-related independent study. The faculty offering the course should submit a research plan to be approved by the BIOE Graduate Program Committee. At the end of the course, the student should submit a report and present his work to the Department Graduate Committee. Graded on a Pass or Fail basis.

Pre-Requisites: BIOE 701

This course enables the student to submit his Ph.D. dissertation proposal and defend it in public. The student passes the course if the Ph. D. dissertation committee accepts the submitted dissertation proposal report and upon successfully passing the Dissertation Proposal Public defense. Pre-requisite: Passing the comprehensive exam

The student has to undertake and complete a research topic under the supervision of a faculty member in order to probe in depth a specific problem in Bioengineering. Graded on a Pass or Fail basis.

Pre-Requisites: BIOE 711